The functions associated with TB ratio ≥ 10 include nucleic acids regulation (Zn-fingers, HAT dimerization, ATPases), proteins of the stress response (Heat Shock, Clp1), Oxidative phosphorylation (Oxidoreductase, Cytochrome C) and transporters (Major facilitator, Lipid transport, ABC transporter). This evidence concerns the gene CYCS and tuberculosis.