The functions associated with TB ratio ≥ 10 include nucleic acids regulation (Zn-fingers, HAT dimerization, ATPases), proteins of the stress response (Heat Shock, Clp1), Oxidative phosphorylation (Oxidoreductase, Cytochrome C) and transporters (Major facilitator, Lipid transport, ABC transporter). Here, TMPRSS11D is linked to tuberculosis.