Specifically, in assessing polymorphisms in the XRCC3 and ERCC2/XPD genes using logistic regression, evidence of an increased risk of bladder cancer among those in the top arsenic exposure decile was observed for those with a variant allele of the double-strand break repair gene XRCC3. Therefore, we focus our analysis on 11 variables that allow us to explore the role of SNPs in the gene XRCC3 at positions 03, 04, and 241 and ERCC2/XPD at positions 03, 09, and 312. This evidence concerns the gene XRCC3 and urinary bladder cancer.