TTN and dilated cardiomyopathy: Mutations associated with dilated cardiomyopathy are overrepresented in the titin A-band [14]; the mutation identified in Swedish HMERF families by Lange et al. [5] is in the titin protein kinase domain, while mutations for TMD, LGMD2J, and EOMFC are located in the C-terminal end of the M-band.