TSC2 and autism: None of the three studies, all of which reported overlapping results with respect to genes conferring susceptibility to autism, identified the mTOR pathway genes that we investigated as genuine autism risk factors, though de novo mutations were identified in two of the genes, MYCBP2 and TSC2. Neale et al.[37] identified a single de novo missense mutation in the myc-binding domain of MYCBP2. The mutation was however predicted to be benign by PolyPhen-2.