TNF and Sepsis: Multiple in vitro and in vivo studies in animal models and also in human has shown that it decreases TNF-α, IFN-γ and IL-2 levels and its effect in some clinical situations, such as experimental inflammatory bowel diseases, immunogenic type-1 diabetes in mouse and also in patients with sepsis and in HIV patients, has been evaluated due to its immunoregulatory properties [8-15].