Previous studies have shown that IMODTM can significantly reduce TNF-α and IL-1 levels [11,12,39],but insignificant effect of IMODTM on these biomarkers in present study may be due to different amount or source of secretion of various biomarkers in AIS; although, further studies measuring biomarkers in serum and CSF may be needed to test this hypothesis. This evidence concerns the gene TNF and androgen insensitivity syndrome.