CD4 and Epstein-Barr virus infection: Although expression of CD56, CD2, CD7 or granzyme B can be common between pDCL and ANKL, However, pDCL can be identified by the following phenotype: CD4±, high expression of CD123 (IL-3α receptor), BDCA-2 ± (blood dendritic cell antigen-2 or CD303±), BDCA-4 ± (CD304±), and it is not associated with EBV infection[12,13].