SMARCB1/INI1 is a highly conserved core subunit of the SWI/SNF family of ATP-dependent chromatin remodeling complexes [1] and acts as a tumor suppressor gene inactivated in malignant rhabdoid tumors (MRT) of childhood, encompassing renal, soft-tissue and brain cancers [2] and characterized by SMARCB1/INI1 genetic inactivation as a primary, recurrent event [3,4]. This evidence concerns the gene SMARCB1 and brain cancer.