CASP3 and cervical cancer: In a separate study, Liu et al. [33] showed that 5 μM ABT-888 co-treatment with the DNA alkylating agent N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) induced activation of caspase-9 and caspase-3 and increased apoptosis in cervical cancer HeLa cells by preventing ATP loss.