REN and hypertensive disorder: The drugs that are currently recommended for the treatment of hypertension in adults are also prescribed for children and adolescents (Table 11): a) renin-angiotensin-aldosterone system blockers, ACE-inhibitors[90-92] and AT1-receptor antagonists, sartans[93-95] (aliskiren, a direct renin inhibitor has not been evaluated in pediatric studies yet); b) beta-blockers[96]; c) calcium-antagonists[97]; d) diuretics[98].