A recent pilot study examining the effects of DNA methylation on cardiovascular-related phenotypes within the San Antonio Family Heart Study (SAFHS) [37] showed suggestive correlation between methylation levels at a CpG site within exon 1 of FABP3 and several metabolic syndrome (MetS)-related phenotypes, including HDL-cholesterol (p=0.0017) and fasting insulin (p=0.0048) (unpublished data; p-values not corrected for multiple testing). The gene discussed is INS; the disease is metabolic syndrome.