Neuroendocrine tumors found in the thymus, thyroid, lungs, adrenals, gastrointestinal tracts and pancreas have been associated with ectopic adrenocorticotropic hormone (ACTH)- dependent Cushing’s syndrome (CS), with small cell lung carcinoma and pulmonary carcinoids accounting for the most cases[1-4]. This evidence concerns the gene POMC and Cowden syndrome 1.