As markers of inflammation have been observed in human PD [13] and peripheral [14] and striatal [15] LPS administration result in inflammation and degeneration of tyrosine hydroxylase (TH) immunopositive cells in the SNpc of adult rats, respectively, we sought to determine whether ghrelin’s neuromodulatory effect may involve attenuation of pro-inflammatory cytokine release from mid-brain dopaminergic neurones. This evidence concerns the gene TH and Parkinson disease.