In addition, our results indicate that overall, the Ad5/F35-APE1 siRNA recombinant adenovirus effectively inhibited the DNA damage repair function of APE1 in A549 cells treated with PDT, enhanced the PDT inhibitory effect on the proliferation of these cells, increased intracellular ROS expression to further influence the release of such inflammatory factors as IL-1β and TGF-β, promoted apoptosis, and increased the lung cancer sensitivity to PDT treatment. Here, TGFB1 is linked to lung cancer.