CD109 has been reported as a TGF-β coreceptor with high affinity for the TGF-β subtype and inhibiting TGF-β signaling in vitro, thus has been studied as a therapeutic target for diseases in which TGF-β may play a pathophysiological role and a key to elucidate pathogenesis of certain cancers [6, 8]. This evidence concerns the gene TGFB1 and cancer.