Moreover, our observation that LDs formation induced by MT-II requires activation of the PI3 K pathway is in line with reports of participation of this signaling protein in processes related to lipid accumulation [26, 44, 45] and in the regulation of PLIN2 which has been largely associated to lipid accumulation into LDs, and to atherosclerosis [26, 45]. Here, MT2A is linked to atherosclerosis.