CD8A and pachyonychia congenita: In a phase I trial, Miyazawa et al. administered a peptide vaccine for human VEGF receptor, (VEGFR)2-169 epitope, in patients with advanced PC, in combination with gemcitabine, observing an antigen-specific DTH and VEGFR2-specific CD8+ cells in 61% patients, with an overall MS time of 8.7 months [101].