TP53 and cancer: They are able to bypass apoptosis, the preferential form of Programmed Cell Death (PCD) induced by conventional cancer therapies, by the loss of Tumor Protein 53 (TP53) tumor suppressor function, the upregulation of antiapoptotic regulators (Bcl-2, Bcl-xL) or of survival signals (Igf1/2), the downregulation of pro-apoptotic factors (Bax, Bim, Puma), or the short-circuiting of the extrinsic ligand-induced death pathway.