In addition, the number and functions of Tregs cells are necessary in controlling autoimmunity since depletion of CD4+CD25+ T cells in mice, mutations in the Foxp3 gene, or environmental agents affecting Treg cells cause or predispose to autoimmunity [116] because the lack in balancing the activity of self-reactive T cells produced in the thymus. This evidence concerns the gene FOXP3 and Autoimmunity.