Also the level of pro-inflammatory systemic cytokines showed similar results as the assessment of arthritis, where a tendency to decrease in the Tc + RA group was observed, but the other groups had similar amounts of IL-1β and IFN-γ; this could be due to the strong effects of the immunization with CFA plus OVA as well as the challenge injection with HAO. Here, IL1B is linked to rheumatoid arthritis.