Also the level of pro-inflammatory systemic cytokines showed similar results as the assessment of arthritis, where a tendency to decrease in the Tc + RA group was observed, but the other groups had similar amounts of IL-1β and IFN-γ; this could be due to the strong effects of the immunization with CFA plus OVA as well as the challenge injection with HAO. Here, IL1B is linked to arthritic joint disease.