ACE and endothelial dysfunction: Pharmacological approach in improving/reversal of endothelial dysfunction was shown to be beneficial in clinical trails that have investigated actions of angiotensin converting enzyme inhibitors, angiotensin receptor blockers, statins and other lipid lowering agents, calcium channel blockers, some β-receptor blockers, thiazolidinediones, erythropoietin, L-arginine, antioxidants, vitamins, tetrahydrobiopterin, or stimulators of endothelial progenitor cells [9, 14, 15].