IFNA1 and Cognitive impairment: Likewise, the prefrontal cortex differential regulation of key gene networks; that is, IL1, NFκB, TNF, IFN, and TLRs are likely players in the significant cognitive deficits observed in children with no risk factors for neurological or cognitive deficits, other than their residency in a highly polluted megacity [29, 32, 33, 77].