Likewise, the prefrontal cortex differential regulation of key gene networks; that is, IL1, NFκB, TNF, IFN, and TLRs are likely players in the significant cognitive deficits observed in children with no risk factors for neurological or cognitive deficits, other than their residency in a highly polluted megacity [29, 32, 33, 77]. This evidence concerns the gene IL1B and Cognitive impairment.