EDN1 and Cognitive impairment: Neuroinflammation, endothelial activation, endothelial cell hyperplasia, the attachment of white blood cells to the endothelial damaged walls with the reduction of the lumen vessel, high blood concentrations of endothelin-1, and the breakdown of the BBB clearly contribute to cognitive impairment and pathogenesis and pathophysiology of neurodegenerative states [125, 126].