A recent study reported that serum amyloid A acting through the formyl-peptide receptor 2/lipoxin receptor (FPR2/ALX) can overwhelm anti-inflammatory signaling by LXA4 to mediate exacerbation of glucocorticoid refractory lung inflammation in patients with chronic obstructive pulmonary disease (Bozinovski et al., 2012). The gene discussed is FPR2; the disease is chronic obstructive pulmonary disease.