CX3CR1 and amyotrophic lateral sclerosis: The CX3CR1 deficiency also effects neuro-inflammatory and neurodegenerative diseases, as established in murine models of Alzheimer's and Parkinson's disease (AD, PD) and amyothrophic lateral sclerosis (ALS), as well as neuropathological conditions, such as neuropathic pain and cerebral ischemia.