Interestingly, recent studies have shown induction of JMJD3 in Epstein Barr virus infected cells and associated Hodgkin’s lymphoma [78]; (5) Lastly, an inverse relationship was noted between protein levels of Plk1 and Suz12/Znf198 in X-induced tumorigenesis [69], suggesting Suz12 and Znf198 are down-regulated via Plk1-mediated phosphorylation, promoting their proteasomal degradation. This evidence concerns the gene SUZ12 and Hodgkins lymphoma.