MAPK8 and neuroblastoma: In human neuroblastoma cell lines, an exposure to 10 and 20 μM of CdCl2 for 24 h led to an increased activity of c-Jun N-terminal kinase (JNK) and extracellular-signal-regulated kinases (ERK) after ROS-induced disruption of serine/threonine phosphatases 2A and 5 [81].