In the present study, after integrating the results of breast cancer microarray dataset analyses using several different models, we identified 21 genes that are closely related to breast cancer recurrence: LMCD1, DEAF1, AP2A2, LMNB1, ZFP36L2, ABCC1, PLOD2, LARS2, CDCA3, AACS, TNFRSF25, SMC1A, ADIPOQ, DPP3, FADD, PLK1, SDS, HSPB6, MTERFD1, CHPF and AQP1. The gene discussed is AACS; the disease is breast cancer.