IL1B and schizophrenia: Although many of the immune compounds were found to be linked to (components of) metabolic syndrome, the most dominant linkage was found with schizophrenia itself, confirming earlier reports of increased monocyte/macrophage activation being a key component for understanding the pathogenesis of schizophrenia, consistent with the meta-analysis showing that IL-1β and IL-6 are trait markers of schizophrenia.