PTPN22 and juvenile idiopathic arthritis: We have confirmed association of JIA with SNPs close-by to c12orf30, c3orf1, PTPN22, STAT4, and TRAF1-C5; and we have provided further support for the association of SNPs close-by to AFF3, CD226, MBL2, PSTPIP1, and CCL5. A limitation of our study was our relatively small sample size; our full dataset had 80% power to detect an OR of 1.4 for an allele at 20% frequency in the population at an alpha of 0.05.