TH and Parkinson disease: Asevidence for this, PD patient IgG and hrC5a (human recombinant complement 5a) induced neurotoxicityin mixed neuron–glia co-cultures (Wang et al., 2007).Similarly, PD patient serum added to dissociated mesencephalic–striatal co-cultures resultedin reduced DA uptake and TH+ cell loss; however, this only occurred when PD patient serum was addedtogether with reconstituted rabbit complement (Defazio et al., 1994).