MRGPR-X1-induced CCR2 expression is of particular interest, considering that CCL2-induced activation of CCR2 in DRG neurons plays a major role in distinct neuropathic pain syndromes, as demonstrated by significantly diminished neuropathic pain responses found in mice deficient of the CCR2 gene [52] and by abolished neuropathy-induced hyperalgesia and allodynia after application of CCR2 specific antagonists to wild-type mice [22], [53]. The gene discussed is CCL2; the disease is neuropathy.