Our aim is to use this technology in order to induce local production of the recombinant scFv-Fc anti-C5 miniantibody MB12/22 (Mubodina®, ADIENNE Pharma & Biotech, Italy) in sufficient amount to prevent complement activation in the joint and to prevent joint inflammation in experimental model of arthritis in rat. This evidence concerns the gene C5 and arthritic joint disease.