To obtain further insights into the potential role of CD44 in metabolic syndrome, we monitored the development of diet-induced hepatic steatosis, adipose-associated inflammation, and type 2 diabetes in WT and CD44KO mice fed with a HFD ((WT(HFD) and CD44KO(HFD), respectively) for 21 weeks. The gene discussed is CD44; the disease is type 2 diabetes mellitus.