To investigate whether added Wnt11 or Wnt5a can modulate E- and N-cadherin expression in LC cell lines, both A549 and H157 cell lines were exposed to rWnt5a and Wnt11 at the concentration of 0.1 and 1.0 μg/ml. The gene discussed is CDH2; the disease is laryngotracheoesophageal cleft.