The additional signals could also include for example different levels of Wnt11 receptor Fzd-7 in NSCLC sub-types that was detected in the AC and SCC samples (unpublished observations), as well as activators of e.g. the SP1, AP1 or AP2 transcription factors that could modify Wnt5a transcription. Here, FZD7 is linked to non-small cell lung carcinoma.