ACE and ischemic stroke: Our study finds a high risk of ACE/DD variant in South Asians (OR 5.00: 95% CI, 1.17–21.37) which accounts for a five-fold increase in the risk of overall ischemic stroke per copy of the risk allele of the ACE DD variant relative to Europeans (OR 1.15: 95% CI, 1.06–1.25) [14].