ACE and ischemic stroke: The homozygous ACE D/D polymorphism was investigated in a total of 2 studies covering India [32], [33] in 693 subjects (355 ischemic stroke cases; 338 controls) providing a pooled OR of 5.00 (95% CI, 1.17–21.37, p = 0.03) with a recessive random-effects model.