The Wellcome Trust Case Control Consortium 2 (WTCCC2) and the International Stroke Genetics Consortium (ISGC) have successfully identified novel genes associated with stroke risk (PITX2, ZFHX3, 9p21 locus and HDAC9) [99] while other GWAS studies have highlighted the subtype specific nature of these genetic effects [100]. This evidence concerns the gene ZFHX3 and stroke disorder.