Given that c-Myb is a key regulator of haematopoiesis, we decided to use the CML-derived erythroleukemic cell line K562, in which numerous c-Myb target genes have been identified [49], and performed siRNA-mediated depletion of c-Myb, PRMT4, Mi2α or Mi2β. Here, CHD3 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.