SCML2 and neoplasm: It will be important to determine whether the role of LIN-61 in DSB repair is conserved in human MBT proteins and whether MBT mutated tumours, such as medulloblastomas with mutations in L3MBTL2, L3MBTL3 or SCML2[10], are HR deficient as they too may prove responsive to treatment with PARP inhibitors.