Finally, miR-191/425 cluster upregulates zonula occludens-1 (ZO-1), a component of the tight junction barrier in epithelial and endothelial cells [52]; E-cadherin (CDH1), an important marker of epithelial tumor progression; and β-catenin (CTNN1) a component of wnt pathway that drives progression in various cancers [53]. Here, TJP1 is linked to cancer.