PGP and cancer: Among the 48 known ABC transporters in humans, elevation of three members, P-gp (MDR1 gene product), Multidrug resistance-associated protein 1 (MRP1) and mitoxantrone resistance protein [MXR; also known as breast cancer resistance protein (BCRP) or placenta ABC protein (ABC-P)], have been correlated with cancer chemoresistance to various drugs (Gottesman, 2002; Gottesman et al., 2002).