6 Kim Kim MJ MJ Jang Jang SJ SJ Yu Yu E E Loss of E-cadherin and cytoplasmic-nuclear expression of beta-catenin are the most useful immunoprofiles in the diagnostis of solid-pseudopapillary neoplasm of the pancreas Loss of E-cadherin and cytoplasmic-nuclear expression of beta-catenin are the most useful immunoprofiles in the diagnostis of solid-pseudopapillary neoplasm of the pancreas Hum Pathol. The gene discussed is CDH1; the disease is Solid Pseudopapillary Neoplasm of the Pancreas.