Sex bias in single-nucleotide polymorphism (SNP) has also been reported recently for tissue factor (TF) and TF pathway inhibitor (TFPI) genes among patients with coronary heart disease and type-2 diabetes (Opstad et al., 2010) and the risk of breast cancer in men (Orr et al., 2011). This evidence concerns the gene F3 and type 2 diabetes mellitus.