ALK and cancer: Both were shown to inhibit the proliferation of cancer cells and the activity of multiple protein kinases such as anaplastic lymphoma kinase (ALK), AMPK-related protein kinase (ARK5), Aurora-B, insulin-like growth factor-1 receptor (IGF1-R), pim kinase-1 (PIM1), polo-like kinase 1 (PLK1), PKC-related kinase 1 (PRK1), Src and VEGFR-2, but anomalin A was more potent and had a different spectrum of action [122,123].