Adding to growing evidence, highlighted above, for cross-talk between TGF-β and other pathways, our recent studies on embryonic stem cells and induced pluripotent stem cells (iPSCs) derived from individuals with Marfan Syndrome (MFS), who carry mutations in FIBRILLIN 1 (FBN1), provided some intriguing insights into the interplay between TGF-β and BMP signaling pathways that are responsible for the skeletogenic phenotype unveiled in these cells. Here, FBN1 is linked to Marfan syndrome.