TLR7 and systemic lupus erythematosus: Significantly higher transcript levels of TLR7, MyD88, and IFN-α were also observed in active SLE patients (median 43.47, IQR 9.30 to 103.07; 2.08, IQR 0.85 to 4.87; 24.91, IQR 6.20 to 188.90, respectively) than those in healthy controls (P <0.001, P <0.05, P <0.001, respectively).