Significantly higher mean fluorescence intensity (MFI) of TLR7 staining on circulating pre-mDCs and mDCs was also observed in patients with active AOSD (median 7.23, IQR 5.00 to 8.69 and 9.30, IQR 6.85 to 11.35, respectively) and in active SLE (median 6.69, IQR 5.69 to 9.84 and 8.80, IQR 7.08 to 10.35, respectively) than in healthy controls (median 3.47, IQR 2.88 to 4.78 and 4.65, IQR 2.98 to 6.00, respectively) (all P <0.001). This evidence concerns the gene TLR7 and adult-onset Still disease.