IRAK4 and adult-onset Still disease: As shown in Figure 2, significantly higher transcript levels of TLR7, MyD88, IRAK4, TRAF6, and IFN-α were observed in active AOSD patients (median 145.64, IQR 7.07 to 814.81; 2.08, IQR 1.53 to 8.55; 4.55, IQR 1.55 to 14.49; 13.86, IQR 4.80 to 45.04; 46.23, IQR 15.51 to 154.05, respectively) than those in healthy controls (0.48, IQR 0.23 to 8.62; 1.12, IQR 0.79 to 1.40; 0.59, IQR 0.51 to 2.62; 0.55, IQR 0.40 to 3.80; 0.61, IQR 0.10 to 11.30, respectively (all P <0.001).