As shown in Figure 4A, the percentages and MFI of TLR7-expressing pre-mDCs significantly decreased (mean ± SEM, 64.78 ± 1.83 vs. 43.95 ± 1.82; 7.19 ± 0.54 vs. 4.90 ± 0.61, respectively, both P <0.001), paralleling clinical remission and the decrease in serum ferritin levels (931.5 ± 201.3 μg/L vs. 234.4 ± 28.3 μg/L, P <0.001) in AOSD patients. The gene discussed is TLR7; the disease is adult-onset Still disease.