TLR7 and adult-onset Still disease: As shown in Figure 1, significantly higher percentages of TLR7-expressing pre-mDCs and mDCs were observed in patients with active AOSD (median 65.5%, IQR 60.2 to 73.7%, and 14.9%, IQR 12.5 to 18.8%; for pre-mDCs and mDCs, respectively) and SLE (median 60.3%, IQR 52.1 to 68.1% and 14.4%, IQR 12.5 to 18.0%, respectively) than in healthy controls (median 42.8%, IQR 36.9 to 51.7% and 8.8%, IQR 5.1 to 11.1%, respectively) (all P <0.001).