Similarly, the transcript levels for TLR7-signaling molecules including TLR7, MyD88, TRAF6, IRAK4, and IFN-α significantly decreased (535.8 ± 207.8 vs. 2.93 ± 2.26, P <0.001; 5.66 ± 1.44 vs. 0.92 ± 0.09, P <0.001; 27.40 ± 7.33 vs. 2.10 ± 0.35, P <0.005; 8.90 ± 2.34 vs. 1.02 ± 0.12, P <0.005; 96.94 ± 26.29 vs. 4.99 ± 1.07, P <0.001, respectively, Figure 4B, C, and D), paralleling the decrease in disease activity score (6.44 ± 0.40 vs. 3.78 ± 0.15, P <0.001) in AOSD patients. This evidence concerns the gene IRAK4 and adult-onset Still disease.