In conclusion, our current data, together with previous findings, suggest that the iDG phenotype is responsible for some of the cognitive deficits observed in SNAP-25 KI, αCaMKII HKO, Shn-2 KO, and pilocarpine-treated mice and in patients with psychiatric disorders, such as schizophrenia, ADHD, and anxiety disorder. Here, SNAP25 is linked to attention deficit-hyperactivity disorder.