In one study that performed in a Hispanic population, 18 different adiponectin gene polymorphisms have been investigated with regard to six different criteria for obesity (BMI – Waist circumference - waist to hip ratio - subcutaneous fat tissue-visceral fat-visceral fat to subcutaneous fat ratio) and among them, several polymorphisms were related to obesity located in promoter region[35]. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.