Moreover, Kaplan-Meier analysis and the log-rank test were used to calculate the effect of MACC1 expression on RFS, and the results showed that RFS was significantly different between the low- and high-MACC1 expression groups (P = 0.002, Figure 2A), strongly indicating that MACC1 overexpression generally correlated with breast cancer recurrence. Here, MACC1 is linked to breast cancer.