While in other cancer types, such as colon cancer, gastric cancer and HCC, MACC1 has been found in fair numbers of patients (n = 41 ~ 60) to be pro-metastatic and predictive of disease prognosis[2,3,6], the clinical significance of MACC1 in breast cancer was not previously studied, and whether it is of prognostic value in breast cancer, particularly for different patient subgroups, required enrollment of sufficient number of clinical cases to reach clinically relevant and meaningful conclusion. The gene discussed is MACC1; the disease is cancer.