Fourth, we could not examine the candidate blood markers for prediction of stroke outcome in the previous studies, including brain natriuretic peptide (BNP or NT-proBNP) [4], midregional pro-atrial natriuretic peptide (MR-proANP) [37], lipoprotein-associated phospholipase A2 (LpPlA2) [38], or copeptin [39]. Here, NPPA is linked to stroke disorder.