Additionally, (a) two of the microarray analyses showed a significant reduction of progesterone receptor levels in high PrP expressing cancers [53,54], (b) one study showed a significant association of high PrP mRNA levels with tumor grade [54], and (c) one study showed a lower age at diagnostic [53] and an increase in metastatic events in high PrP mRNA tumors [53]. This evidence concerns the gene PRNP and neoplasm.