Our results using RT-PCR show that NPC express all FGFR tested, with the exception of FGFR2-IIIB, and that the expression of FGFR1 and FGFR2-IIIC were up-regulated at 30 and 120 minutes by HA with a transient decrease at 60 minutes. This evidence concerns the gene FGFR1 and nasopharyngeal carcinoma.