There were 2 indels in MUC2, 10 indels and point variants in MUC4, as well as 1 indel and 1 point variant in MUC12. Since the expression of mucin proteins has been correlated with aggressiveness of colorectal cancer [38], the excess of disruptive variants in mucin genes further confirmed their importance in colorectal carcinogenesis. This evidence concerns the gene MUC12 and colorectal cancer.